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Op-Ed: We Like Ike to Fight COVID-19 War

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America is at war! We are fighting a malicious, microscopic, worldwide enemy that has already killed more in the U.S. than the total number of U.S. troops and civilians lost in World War II. In fact, we can find no more appropriate equivalency than WWII.
Even after 80 years, we still marvel at the accomplishments of the home front, totally mobilized on behalf of the war effort. The automotive industry completely shut down car production and re-tooled in record time to produce tanks and planes. The Kaiser shipyards, built from scratch, turned out thousands of Liberty ships. And let us not forget the Manhattan Project, the unprecedented mobilization of scientific and engineering talent operating under terrifying time pressure. At home, average Americans, ever fearful for loved ones overseas, sacrificed by accepting the rationing of sugar, meat, and gasoline. ....

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'Toci' and COVID; Exercise for Arthritic Knees; It's TTHealthWatch!

Rick Lange: Do people with COVID benefit from a blood thinner?
Elizabeth: A really exhaustive look so far at the human gut microbiome and how it may be related to disease.
Rick: And a different anti-inflammatory medication for people with COVID and respiratory problems.
Elizabeth: That s what we re talking about this week on TT HealthWatch, your weekly look at the medical headlines from Texas Tech University Health Sciences Center in El Paso. I m Elizabeth Tracey, a Baltimore-based medical journalist.
Rick: And I m Rick Lange, president of the Texas Tech University Health Sciences Center in El Paso, where I m also the dean of the Paul L. Foster School of Medicine. ....

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Vitamin D Flops in Moderate-Severe COVID

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Among patients with moderate to severe COVID-19, there was no difference in length of hospital stay in those given a single 200,000-IU dose of vitamin D
3 versus those given placebo in a randomized trial in Brazil.
Median length of hospital stay was about 7 days for both groups, with no significant differences in secondary outcomes including in-hospital mortality, admission to ICU, or need for mechanical ventilation, reported Rosa Pereira, MD, PhD, of Universidade de Sao Paulo, and colleagues in an online edition of
An accompanying editorial by David Leaf, MD, of Brigham and Women s Hospital in Boston, and Adit Ginde, MD, MPH, of University of Colorado School of Medicine in Aurora, noted that prior research showed that lower levels of vitamin D were independently associated with worse outcomes in patients with acute illness, but also that vitamin D supplementation as a treatment had no impact on clinical outcomes. ....

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Another Drug Shows Mortality Benefit for Severe COVID-19

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Tocilizumab (Actemra) showed a slight but statistically significant mortality benefit in critically ill COVID-19 patients, according to a press release from the U.K. s pragmatic RECOVERY trial.
Of patients treated with tocilizumab, an IL-6 inhibitor used for rheumatoid arthritis and related conditions, 29% died within 28 days versus 33% of patients treated with usual care (rate ratio 0.86, 95% CI 0.77-0.96,
P 0.007), researchers stated. This amounted to a number needed to treat of 25 to save one additional life.
And tocilizumab improved the probability of discharge alive after 28 days, from 47% to 54% (RR 1.23, 95% CI 1.12-1.34,
P 0.0001) among hospitalized patients of varying severity, from those needing supplemental oxygen to those requiring intubation. ....

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How Much Protection Do Babies Get From Mom's COVID Antibodies?

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Mothers with COVID-19 produced a robust antibody response, but transfer of antibodies across the placenta to their infants was less efficient than expected, researchers found.
In an analysis of pregnant women who had COVID-19, neutralizing activity which measures the potency of antibody response was detected in 94% of maternal blood samples and only 25% of cord blood, according to Naima Joseph, MD, MPH, of Emory University in Atlanta, and colleagues.
The overall cord-to-maternal anti-receptor binding (RBD) immunoglobulin (Ig)G ratio was 81%, Joseph reported at the Society for Maternal-Fetal Medicine annual meeting.
There is a maternal antibody response that is robust following infection, Joseph said in her presentation. But while she emphasized that anti-RBD domain IgG titers were detected in umbilical cord samples, she said it was unexpected that the efficiency of transfer was less than 1. ....

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