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IMAGE: Jessica H. Beard, MD, MPH, FACS, Assistant Professor of Surgery and Director of Trauma Research at the Lewis Katz School of Medicine at Temple University. view more
Credit: Temple University Health System
(Philadelphia, PA) - While the COVID-19 pandemic brought most of the country to a standstill in March 2020, Philadelphia trauma surgeons noticed an alarming trend in the incidence of firearm violence. Instead of decreasing with containment measures, firearm-injured patients were presenting at even higher rates to Temple University Hospital and other trauma centers around the city.
A team led by Jessica H. Beard, MD, MPH, FACS, Assistant Professor of Surgery and Director of Trauma Research at the Lewis Katz School of Medicine at Temple University (LKSOM), sought to determine the magnitude of Philadelphia s increase in firearm violence during the COVID-19 pandemic. They also aimed to understand potential causes of the increase by trying to pinpoint when
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(Philadelphia, PA) - Like a failing fuel pump that causes a loss of engine power in a car, a diseased heart can take a serious toll on the body s performance. For some patients, tasks like walking up a flight of stairs or walking across a room eventually turn into exhausting endeavors. This is because, over time, regardless of the underlying cause, heart damage typically progresses, owing to a constant barrage of oxidative stress and toxic lipids that alter heart cell energetics and, ultimately, the ability of the heart to function normally.
Oxidative stress occurs when harmful oxygen-containing molecules outnumber helpful antioxidants, leading to damaging reactions with proteins, DNA, and other cell components. Now, in two new studies, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) show that in the heart, one molecule in particular, Kruppel-like factor (KLF)-5, single-handedly fuels both the generation of oxidizing molecules and the accumul
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