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Changing the treatment paradigm for 'cold' tumors


Changing the treatment paradigm for ‘cold’ tumors
Not all cancerous tumors are created equal. Some tumors, known as hot tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy drugs can then amp up the immune response.
Cold tumors, on the other hand, have no T-cell infiltration, which means the immune system is not stepping in to help. With these tumors, immunotherapy is of little use.
It s the latter type of tumor that researchers Michael Knitz and radiation oncologist and University of Colorado Cancer Center member Sana Karam, MD, PhD, address in new research published this week in the ....

United States , Sana Karam , Michael Knitz , Thomas Bickett , Emily Henderson , University Of Colorado Cancer Center Member , University Of Colorado School Medicine , University Of Colorado Cancer Center , Colorado Cancer Center , Colorado School , ஒன்றுபட்டது மாநிலங்களில் , சனா கரம் , தாமஸ் பிக்கெட் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கொலராடோ பள்ளி மருந்து , பல்கலைக்கழகம் ஆஃப் கொலராடோ புற்றுநோய் மையம் , கொலராடோ புற்றுநோய் மையம் , கொலராடோ பள்ளி ,

A new method for fighting 'cold' tumors


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Not all cancerous tumors are created equal. Some tumors, known as hot tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy drugs can then amp up the immune response.
Cold tumors, on the other hand, have no T-cell infiltration, which means the immune system is not stepping in to help. With these tumors, immunotherapy is of little use.
It s the latter type of tumor that researchers Michael Knitz and radiation oncologist and University of Colorado Cancer Center member Sana Karam, MD, PhD, address in new research published this week in the ....

United States , Sana Karam , Michael Knitz , Thomas Bickett , University Of Colorado School Medicine , University Of Colorado Cancer Center , Colorado Cancer Center , Colorado School , ஒன்றுபட்டது மாநிலங்களில் , சனா கரம் , தாமஸ் பிக்கெட் , பல்கலைக்கழகம் ஆஃப் கொலராடோ பள்ளி மருந்து , பல்கலைக்கழகம் ஆஃப் கொலராடோ புற்றுநோய் மையம் , கொலராடோ புற்றுநோய் மையம் , கொலராடோ பள்ளி ,

Study reveals how DNA segments function in cells


Study reveals how DNA segments function in cells
A new study co-authored by University of Colorado Cancer Center researcher Srinivas Ramachandran, PhD, shows how DNA segments known as enhancers function in cells.
The paper published last month in
Molecular Cell highlighted the work from Ramachandran, along with Satyanarayan Rao, both part of the Department of Biochemistry and Molecular Genetics at the CU School of Medicine, and Kami Ahmad from the Fred Hutchinson Cancer Research Center.
Enhancers are DNA sequences that drive cell-type-specific gene expression, developmental transitions, and cellular responses to external stimuli. They typically have multiple binding sites for transcription factors, which are proteins that help turn specific genes on or off by binding to nearby DNA. ....

United States , Kami Ahmad , Satyanarayan Rao , Srinivas Ramachandran , Emily Henderson , Cu School Of Medicine , School Of Medicine , University Of Colorado , University Of Colorado Cancer Center , Department Of Biochemistry , Fred Hutchinson Cancer Research Center , Colorado Cancer Center , Molecular Cell , Molecular Genetics , Fred Hutchinson Cancer Research , Transcription Factors , Ene Expression , ஒன்றுபட்டது மாநிலங்களில் , சத்தியநாராயண் ராவ் , ஸ்ரீநிவாஸ் ராமச்சந்திரன் , எமிலி ஹென்டர்சன் , சு பள்ளி ஆஃப் மருந்து , பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் கொலராடோ , பல்கலைக்கழகம் ஆஃப் கொலராடோ புற்றுநோய் மையம் , துறை ஆஃப் உயிர் வேதியியல் ,