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WORLD / EUROPE Partial sight restored in blind man By AFP Published: May 25, 2021 08:28 PM Scientists have for the first time managed to partially restore the sight of a blind patient by altering his cells, according to the results of a groundbreaking study published on Monday. A visually impaired student reads Braille during an online class on World Braille Day on January 4 in Surabaya, Indonesia. Photo: VCGThe technique known as optogenetics, which has been developed in the field of neuroscience over the last 20 years, involves genetically altering cells so they produce more light-sensitive proteins. In some cases of blindness, known as inherited photoreceptor diseases, light-sensing cells in the retina that use proteins to deliver visual information to the brain via the optic nerve progressively degenerate. ....
email article Optogenetic therapy restored partial vision in a blind 58-year-old man diagnosed with retinitis pigmentosa almost 40 years ago, according to a case report from the ongoing PIONEER study. In this open-label phase I/IIa study, intraocular injection of an optogenetic sensor-expressing gene therapy vector combined with use of light-stimulating goggles was found to partially restore visual function in a patient with visual acuity of only light perception, reported José-Alain Sahel, MD, of the University of Pittsburgh, and colleagues in Retinitis pigmentosa is an inherited neurodegenerative disease that breaks down light-receptive cells in the retina and can lead to complete blindness. More than 2 million people worldwide are affected by this progressive disease. There is no approved treatment, except for a gene replacement therapy that works only in an early-onset form of the disease caused by a mutation in the ....
Sahel et al, Nature Medicine and StreetLab/Institut de la Vision A man who is blind has had glimmers of vision restored thanks to a high-tech treatment using optogenetics, which involves genetically altering nerve cells so they respond to light. French firm GenSight Biologics has published results showing that the first recipient of its treatment can recognise different objects in lab tests. “It’s exciting to see the first publication on human optogenetics,” says Ed Boyden at the Massachusetts Institute of Technology in Boston, a co-inventor of optogenetics. Advertisement Optogenetics has become a widely used lab tool, because it allows precision control over brain cells by altering them so they fire in response to light. It has led to many discoveries about the brain when used in animals – but is thought to have limited medical potential for treating brain disorders in people, because getting light inside the head requires implanting a fibre optic cable. ....
Blind man regains partial sight after scientists alter his cells in groundbreaking study Scientists in Europe and the US recruited a man who had lost his sight due to an inherited photoreceptor disease 40 years ago They treated him with a technique known as optogenetics, which involves genetically altering cells so they produce more light-sensitive proteins ....