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Results in blood cancer improved by ensuring gut integrity: Study

Results in blood cancer improved by ensuring gut integrity: Study
ANI |
Updated: Feb 13, 2021 19:54 IST
Washington [US], February 13 (ANI): A solitary strain of Bacteroides fragilis altogether diminished graft-versus-host disease (GVHD) by ensuring gut integrity, suggested the findings of a new study led by cancer researchers of Medical University of South Carolina (MUSC).
The findings reported in JCI Insight showed that even though bone marrow transplant can be a lifesaving procedure for patients with blood cancers; however, GVHD is a potentially fatal side effect of transplantation, and it has limited treatment options. This proof-of-concept study demonstrates that better treatment options may be on the horizon for patients with GVHD. ....

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Ensuring gut integrity may improve results in blood cancer: Study

Ensuring gut integrity may improve results in blood cancer: Study
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Washington [US], February 11 (ANI): A new study led by cancer researchers of Medical University of South Carolina (MUSC) found that a solitary strain of Bacteroides fragilis altogether diminished graft-versus-host disease (GVHD) by ensuring gut integrity.The findings reported in JCI Insight shows that even though bone marrow transplant can be a lifesaving procedure for patients with blood cancers; however, GVHD is a potentially fatal side effect of transplantation, and it has limited treatment options. This proof-of-concept study demonstrates that better treatment options may be on the horizon for patients with GVHD.Xue-Zhong Yu, M.D., associate director of Basic Science at Hollings Cancer Center, and lead author Hanief Sofi, Ph.D., realized that protecting the health of the gastrointestinal tract is a good target for reducing severe GVHD. If we can figure out how to keep a patie ....

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Single strain of bacteria may reduce the severity of graft-versus-host disease

Single strain of bacteria may reduce the severity of graft-versus-host disease
MUSC Hollings Cancer Center researchers found that a single strain of bacteria may be able to reduce the severity of graft-versus-host disease (GVHD), as reported online in February 2021 in
JCI Insight.
Bone marrow transplant can be a lifesaving procedure for patients with blood cancers. However, GVHD is a potentially fatal side effect of transplantation, and it has limited treatment options. This proof-of-concept study demonstrates that better treatment options may be on the horizon for patients with GVHD.
Xue-Zhong Yu, M.D., associate director of Basic Science at Hollings Cancer Center, and lead author Hanief Sofi, Ph.D., realized that protecting the health of the gastrointestinal tract is a good target for reducing severe GVHD. ....

Xue Zhong Yu , Hanief Sofi , Emily Henderson , Hollings Cancer Center , Science At Hollings Cancer Center , Cancer Center , Basic Science , Associate Director , Hollings Cancer , Bone Marrow , Bone Marrow Transplant , Gastro Intestinal Tract , Immune System , கிஷுே ஜாங் யூ , எமிலி ஹென்டர்சன் , புற்றுநோய் மையம் , அடிப்படை அறிவியல் , இணை இயக்குனர் , எலும்பு மஜ்ஜை , எலும்பு மஜ்ஜை மாற்று , காஸ்ட்ரோ குடல் பாதை , நோய் எதிர்ப்பு சக்தி அமைப்பு ,

STING activation reduces graft-versus-host disease in a mouse model

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IMAGE: Dr. Xue-Zhong Yu and his research team s findings suggest there could be a new way to protect bone marrow transplant recipients from graft-versus-host disease.
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Credit: MUSC Hollings Cancer Center
MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD). Bone marrow transplant, a treatment for certain blood cancers, is accompanied by potentially life-threatening GVHD in nearly 50% of patients. A January 2021 paper published in
Cellular and Molecular Immunology revealed that activating a molecule called STING may be a new approach to reduce GVHD.
Xue-Zhong Yu, M.D., professor in the Department of Microbiology and Immunology, focuses on understanding the intricate immune mechanisms that regulate GVHD development and anti-tumor activity. ....

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STING controversy: STING activation reduces graft-versus-host disease in a mouse model

MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD). Bone. ....

Xue Zhong Yu , Yongxia Wu , Musc Hollings Cancer Center , Department Of Microbiology , National Institutes Of Health , Laboratory Medicine , Wistar Institute , Cancer Center , Molecular Immunology , National Institutes , Smartstate Endowment , Cancer Stem Cell Biology , Medical University Of South Carolina , Bone Marrow Transplantation , Mortality Rates , Blood Cancer , Cell Biology , Immune Cells , கிஷுே ஜாங் யூ , துறை ஆஃப் நுண்ணுயிரியல் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஆய்வகம் மருந்து , புற்றுநோய் மையம் , மூலக்கூறு நோயெதிர்ப்பு , தேசிய நிறுவனங்கள் , புற்றுநோய் தண்டு செல் உயிரியல் ,