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STING activation reduces graft-versus-host disease in a mouse model

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IMAGE: Dr. Xue-Zhong Yu and his research team s findings suggest there could be a new way to protect bone marrow transplant recipients from graft-versus-host disease.
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Credit: MUSC Hollings Cancer Center
MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD). Bone marrow transplant, a treatment for certain blood cancers, is accompanied by potentially life-threatening GVHD in nearly 50% of patients. A January 2021 paper published in
Cellular and Molecular Immunology revealed that activating a molecule called STING may be a new approach to reduce GVHD.
Xue-Zhong Yu, M.D., professor in the Department of Microbiology and Immunology, focuses on understanding the intricate immune mechanisms that regulate GVHD development and anti-tumor activity. ....

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STING controversy: STING activation reduces graft-versus-host disease in a mouse model

MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD). Bone. ....

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