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Connecting early response and later outcome in COVID-19, centenarians' unique microbiomes, T cell exhaustion in cancer, and more

Connecting early response and later outcome in COVID-19, centenarians' unique microbiomes, T cell exhaustion in cancer, and more
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Jon Rennhack , Vincent Miao , Ryan Tewhey , Catherine Wu , Pardis Sabeti , Chao Dai , Giacomo Oliveira , Sagar Gosai , Ramnik Xavier , Kathleen Yates , Alex Shalek , Steven Reilly , Kim Stegmaier , Nicholas Haining Merck , Anna Owings , Carly Ziegler , Hera Vlamakis , Bo Kyung Seong , Schmidt Fellowluke Oconnor , Damian Plichta , Broad Institute , Cancer Program , Microbiome Program , Keio University School Of Medicine , Research Roundup , Jackson Laboratory ,

Nasal swabs reveal muted antiviral response in patients who developed severe COVID-19


Nasal swabs reveal muted antiviral response in patients who developed severe COVID-19
Over the past 18 months, researchers have learned much about COVID-19 and its viral cause, SARS-CoV-2. They know how the virus enters the body, coming in through the nose and mouth and beginning its infection in the mucus layers of the nasal passageway. They know that infections that remain in the upper airway are likely to be mild or asymptomatic, while infections that progress down the airway to the lungs are much more severe and can lead to fatal diseases. And they have identified common risk factors for severe diseases, like age, gender, and obesity. But there are still many unanswered questions such as when, and where, the course of severe COVID-19 is determined. Does the pathway to severe disease begin only after the body has failed to control mild disease, or could it start much earlier than that? ....

New York , United States , Carly Ziegler , Sarah Glover , Alex Shalek , Bruce Horwitz , Emily Henderson , Broad Institute , University Of Mississippi Medical Center , National Institute Of Diabetes , Division Of Digestive Diseases , Harryb Helmsley Charitable , Ragon Institute , National Institute On , Susan Smith Family Foundation , Research Foundation , National Institute , Technology Program , Colitis Foundation , York Stem Cell Foundation , Institute For Medical Engineering Science , Health Science , Harvard Medical School , Division Of Emergency Medicine , Chan Zuckerberg Initiative , Department Of Chemistry ,