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Photo Credit: Image by Gerd Altmann from Pixabay Being constantly hungry, no matter how much you eat â that’s the daily struggle of people with genetic defects in the brain’s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....
E-Mail Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....
By William Weir February 12, 2021 Share this with FacebookShare this with TwitterShare this with LinkedInShare this with EmailPrint this (Photo credit: Dean Drobot/Shutterstock.com) There are a few ways we perceive food, and not all are particularly well-understood. We know that much of it happens in the olfactory bulb, a small lump of tissue between the eyes and behind the nose, but how the stimuli arrive at this part of the brain is still being worked out. How these stimuli are processed in the brain plays a major role in our daily life. Fully understanding how our perceptions of food are formed is critical, Fahmeed Hyder said, but getting a clear picture of what our brains do when we smell has been tricky. ....