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Existing drug may be effective in treating SARS-CoV-2


Existing drug may be effective in treating SARS-CoV-2
Scientists from the University of Chicago have found that the drug masitinib may be effective in treating COVID-19.
The drug, which has undergone several clinical trials for human conditions but has not yet received approval to treat humans, inhibited the replication of SARS-CoV-2, the virus that causes COVID-19, in human cell cultures and in a mouse model, leading to much lower viral loads.
X-ray crystallography gave us a strong indication of how this drug works, and we became confident that it has a chance to work in humans.
Nir Drayman, University of Chicago ....

Glenn Randall , Andrzej Joachimiak , Savas Tay , Emily Henderson , University Of Chicago , Argonne National Laboratory , Structural Biology Center , University Of Louisville , Us Department Of Energy , Howard Taylor Ricketts Laboratory , Pritzker School , Molecular Engineering , Advanced Photon Source , Energy Office , Science User Facility , Nir Drayman , Howard Taylor Ricketts , க்ளென் ரேண்டால் , சவாஸ் தாய் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , ஆர்கோன் தேசிய ஆய்வகம் , கட்டமைப்பு உயிரியல் மையம் , பல்கலைக்கழகம் ஆஃப் லூயிஸ்வில்லி , எங்களுக்கு துறை ஆஃப் ஆற்றல் , பிரீதிஜ்கேர் பள்ளி ,

Scientists identify existing drugs that may inhibit SARS-CoV-2 virus


Scientists identify existing drugs that may inhibit SARS-CoV-2 virus
The COVID-19 pandemic has caused more than 600,000 deaths in the United States since the start of 2020 and more than 4 million globally. The search for effective treatments against the disease are ongoing, and one hurdle is that SARS-CoV-2, the virus that causes COVID-19, has a number of tricks up its molecular sleeve when it comes to infecting people.
In a recent study published in Nature Communications Biology, researchers from the U.S. Department of Energy s (DOE) Argonne National Laboratory and the University of Chicago identified a way to interfere with a sneaky mechanism the virus uses to prevent a response from an infected person s immune system. ....

United States , Youngchang Kim , Natalia Maltseva , Andrzej Joachimiak , William Jorgensen , Karen Anderson , Emily Henderson , Yale University , Yale Cancer Center , Nature Communications Biology , Us Department Of Energy , American Chemical Society , Office Of Science User Facility At Argonne , Argonne National Laboratory , University Of Chicago , Structural Biology Center , Chemistry Department , Advanced Photon Source , Science User Facility , American Chemical , Sterling Professor , ஒன்றுபட்டது மாநிலங்களில் , வில்லியம் ஜோர்கென்சன் , கரேன் ஆண்டர்சன் , எமிலி ஹென்டர்சன் , யேல் பல்கலைக்கழகம் ,