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Devastating liver disease itching turns out to have a surprising cause


Devastating liver disease itching turns out to have a surprising cause
A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation.
The finding, which appears April 2 in
Gastroenterology, indicates that the keratinocyte cells of the skin surface are acting as what lead researcher Wolfgang Liedtke, MD PhD, calls pre-neurons.
The skin cells themselves are sensory under certain conditions, specifically the outermost layer of cells, the keratinocytes.
Wolfgang Liedtke, Professor of Neurology, Duke School of Medicine ....

Wolfgang Liedtke , Yong Chen , Emily Henderson , Rockefeller University , Duke School Of Medicine , Wake Forest University , Duke School , ஓநாய் லிெடுட்கே , யோங் சென் , எமிலி ஹென்டர்சன் , ராக்ஃபெல்லர் பல்கலைக்கழகம் , டியூக் பள்ளி ஆஃப் மருந்து , எழுந்திரு காடு பல்கலைக்கழகம் , டியூக் பள்ளி ,

Maddening itch of liver disease comes from a surprising source


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IMAGE: Excess lipids produced by liver failure signal an itching sensation directly to the skin cells, through a receptor called TRPV4 and a microRNA.
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Credit: Wolfgang Liedtke, Duke University
DURHAM, N.C. - A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation.
The finding, which appears April 2 in
Gastroenterology, indicates that the keratinocyte cells of the skin surface are acting as what lead researcher Wolfgang Liedtke, MD PhD, calls pre-neurons. ....

Michele Yeo , Wolfgang Liedtke , Andrease Kremer , Yong Chen , Piotr Milkiewicz , Apoyoa Proyectos , Tonye Reeves , Frank Lammert , Rong Ji , Saral Morales , Cienciay Tecnolog , Marcin Krawczyk , Xin Zhang , Andrey Bortsov , Qiao Juan Zhang , Qian Zeng , Anna Mae Diehl , Jennifery Zhang , Andrea Nackley , Mei Chuan Ko , Johannes Morstein , Carlene Moore , Manal Abdelmalek , Tamara Rosenbaum , Rockefeller University , Duke School Of Medicine ,