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Maddening itch of liver disease comes from a surprising source


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IMAGE: Excess lipids produced by liver failure signal an itching sensation directly to the skin cells, through a receptor called TRPV4 and a microRNA.
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Credit: Wolfgang Liedtke, Duke University
DURHAM, N.C. - A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation.
The finding, which appears April 2 in
Gastroenterology, indicates that the keratinocyte cells of the skin surface are acting as what lead researcher Wolfgang Liedtke, MD PhD, calls pre-neurons. ....

Michele Yeo , Wolfgang Liedtke , Andrease Kremer , Yong Chen , Piotr Milkiewicz , Apoyoa Proyectos , Tonye Reeves , Frank Lammert , Rong Ji , Saral Morales , Cienciay Tecnolog , Marcin Krawczyk , Xin Zhang , Andrey Bortsov , Qiao Juan Zhang , Qian Zeng , Anna Mae Diehl , Jennifery Zhang , Andrea Nackley , Mei Chuan Ko , Johannes Morstein , Carlene Moore , Manal Abdelmalek , Tamara Rosenbaum , Rockefeller University , Duke School Of Medicine ,