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Science for just $15 USD. Short circuiting solid tumors Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells without affecting healthy cells and avoiding tumor escape due to antigen loss. To address these challenges, Hyrenius-Wittsten et al. and Choe et al. developed synthetic Notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma. In both studies, the authors demonstrated that synNotch-CAR T cells were better at controlling tumors than traditional CAR T cells and did not result in toxicity or damage to healthy tissue. These results suggest that synNotch-CAR T cells may be an effective treatment strategy for solid tumors. ....
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Technuter At a virtual event attended by partners and clients around the world, Xerox unveiled the following innovations: A Color Accelerator module for Baltoro, expanding inkjet applications and adding ink-saving automation Addition of fluorescent pink to the Iridesse Production Press, enhancing its metallics, white and clear color palette Two new printers capable of higher volumes, more media and extended color options in the Versant family Two Xerox Nuvera AI-enabled media manager software that enables high-quality images with minimal set-up and staff time Automated workflow updates to seamlessly print embellishments with FreeFlow Core 6.0 As the leader in the production color market, Xerox is committed to helping customers expand their business, enhance productivity with new technology and protect their existing investments with new tools and features. ....