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Abscopal Effect for Prostate Cancer? Does This Really Hold Promise? urotoday.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from urotoday.com Daily Mail and Mail on Sunday newspapers.
Partnering up with Abiraterone Acetate – Potentials for a Harmonious Relationship Published 03 May 2021 Abiraterone acetate has demonstrated benefit across the metastatic prostate cancer spectrum when combined or layered on conventional androgen deprivation therapy. Whether it be metastatic castration-sensitive (mCSPC) or metastatic castration-resistant prostate cancer (mCRPC) in either the pre-or the post-docetaxel setting, the overall survival benefit is certain. 1-4 Attempts to advance to the next level with additional agents added to abiraterone acetate, in the first-line mCRPC setting, have been met with mixed results. At this time, other than the continuing foundation of androgen deprivation therapy, there is no therapeutic agent regulatory approved for combination with abiraterone acetate. ....
Published 01 April 2021 Adjuvant therapy trials for urothelial carcinoma have traditionally been challenging to perform. Radical cystectomy is a significantly morbid procedure that leads to high complication and readmission rates. Hence, many patients are not fit to receive any adjuvant therapy after definitive local therapy due to a compromised health situation. At this time, neoadjuvant chemotherapy is still the definitive standard. 1 However, not all patients receive neoadjuvant therapy for a multitude of reasons. For those who did not receive neoadjuvant cisplatin combination chemotherapy, common sense warrants strong consideration of adjuvant therapy as long as a patient is fit and interested. However, we have extremely limited evidence on what to do if a patient has residual muscle invasive disease after prior receipt of neoadjuvant combination cisplatin-based chemotherapy. This is clearly an unmet need population due to the very poor prognosis. ....
How has one year of the coronavirus pandemic changed you? That was the question we posed to readers for the anniversary of the Bay Area’s first shelter-in-place orders on March 17, 2020. Approximately 200 people responded with tributes to the loved ones they lost, celebrations of the passions they found and reflections on trying to survive this strange and difficult time. Today, one year after we started sheltering, here is a selection of their responses, lightly edited for length and clarity. Sarahbeth Maney, Special To The Chronicle I ve walked and walked and walked. + I ve been furloughed from my job since March 2020, so until the restrictions ease up enough to resume, I am home-based and without much of a schedule of appointments or commitments. So what have I done? I ve walked and walked and walked. I walk every day, usually for at least 2 or 3 miles, sometimes as far as 4 or 5 miles. For the past year, I haven t been anywhere that I couldn t walk to, but ....
Published 01 March 2021 It’s now been 3.5 years since I last wrote anything about testicular germ cell tumors and ongoing clinical trials. 1 Although we still cure most men afflicted with this disease, we have not made any major new therapeutic advancements since I wrote that last article. Approximately, 15-20% of patients with metastatic germ cell tumors will relapse following initial chemotherapy. Even in this situation, approximately 50% can still be cured with salvage treatments, either with more conventional cisplatin-based chemotherapy or with high-dose chemotherapy and autologous stem cell rescue. 2-4 However, patients with cisplatin-refractory disease or progressive disease following high-dose salvage chemotherapy and autologous stem cell rescue, harbor an extremely dim prognosis. In these situations, palliative chemotherapy, with regimens containing oxaliplatin, is limited in efficacy, and targeted biologic therapies have also shown limited effic ....