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Future Opportunities in Genitourinary Cancers

Siamak Daneshmand, MD, provides closing remarks on the management of genitourinary cancers and the future of care. ....

European Society For Medical Oncology Congress , Sia Daneshmand , European Society , Medical Oncology Congress , Genomic Landscape , Circulating Tumor Dna , Adjuvant Setting , Locally Advanced Bladder Cancer , Low Grad Tumors , Intermediate Risk Patient Population ,

Is Adjuvant Therapy a New Standard for Urothelial Carcinoma?

Published 01 April 2021
Adjuvant therapy trials for urothelial carcinoma have traditionally been challenging to perform. Radical cystectomy is a significantly morbid procedure that leads to high complication and readmission rates. Hence, many patients are not fit to receive any adjuvant therapy after definitive local therapy due to a compromised health situation. At this time, neoadjuvant chemotherapy is still the definitive standard.
1 However, not all patients receive neoadjuvant therapy for a multitude of reasons. For those who did not receive neoadjuvant cisplatin combination chemotherapy, common sense warrants strong consideration of adjuvant therapy as long as a patient is fit and interested.
However, we have extremely limited evidence on what to do if a patient has residual muscle invasive disease after prior receipt of neoadjuvant combination cisplatin-based chemotherapy. This is clearly an unmet need population due to the very poor prognosis. ....

Fred Hutchinson Cancer Research Center , United States , University Of Washington , Comunidad Autonoma De Cataluna , Evan Yu , Clinical Research Division , Clinical Research Service , Spanish Oncology Genitourinary Group , Seattle Cancer Care Alliance , Clinical Research , Fred Hutchinson Cancer Research Consortium , University Of Washington School Medicine , Division Of Oncology , Department Of Medicine , Advanced Bladder Cancer , Therapy Trials , High Risk Urothelial , Washington School , Clinical Research Director , Genitourinary Oncology , Medical Director , Cystectomy Compared , Cystectomy Alone , Locally Advanced Bladder Cancer , Eur Urol , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி மையம் ,