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$1.2M supports 5 oncology drug development teams - Lab Canada


 
OICR’s Drug Discovery Team is made up of 26 drug discovery scientists housed in state-of-art facilities with a mission to help Ontario’s researchers efficiently translate cancer related discoveries into novel oncology therapies. This team has “identified five of the most promising early stage oncology drug development projects in the province,” said Dr. Tom Hudson, the OICR’s president and scientific director. “OICR is pleased to support these Ontario-based research projects and we look forward to collaborating with our partners to help move them to the next stage of development,” he added.
 
The selected projects address a range of cancers, including hematological malignancies, triple negative breast cancer and colon cancer. They come from major institutions across Ontario and were selected from a province-wide call for proposals to identify promising oncology research that would benefit from OICR’s expertise in drug discovery. ....

Liliana Attisano , Jeff Wrana , David Andrews , Maria Rozakis , Tom Hudson , Aaron Schimmer , University Health Network , Drug Discovery Program , Drug Discovery Team , University Of Toronto , Lunenfeld Tanenbaum Research Institute , Sunnybrook Health Sciences Centre , Sinai Health System , Ontario Institute For Cancer Research , Ontario Institute , Cancer Research , Discovery Team , Sinai Health , Rima Al Awar , Discovery Program , டேவிட் ஆண்ட்ரூஸ் , டோம் ஹட்சன் , ஆரோன் ஸ்கிம்மர் , பல்கலைக்கழகம் ஆரோக்கியம் வலைப்பின்னல் , மருந்து கண்டுபிடிப்பு ப்ரோக்ர்யாம் , மருந்து கண்டுபிடிப்பு அணி ,

Scientists discover two unique subtypes of a prominent mutation in patients with AML


Scientists discover two unique subtypes of a prominent mutation in patients with AML
Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) – called NPM1 – that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation.
In research published Feb. 16, in
Nature Communications, a team led by Princess Margaret Cancer Centre Senior Scientists, Drs. Benjamin Haibe-Kains, Aaron Schimmer and Mark Minden, have discovered that within the NPM1 mutation of AML there exists two unique subtypes, one of which can be effectively treated with drugs already in use. ....

Benjamin Haibe Kains , Mark Minden , Andrea Arruda , Emily Henderson , Aaron Schimmer , University Of Toronto , Nature Communications , University Health Network , Leukemia Live Cell Tissue Bank , Princess Margaret Cancer Centre Senior Scientists , Acute Myeloid Leukemia , Research Director , Princess Margaret , University Health , Associate Professor , Medical Biophysics , Senior Scientist , Princess Margaret Cancer , பெஞ்சமின் ைபே கைன்ஸ் , குறி மீண்டேன் , ஆண்ட்ரியா ஆருட , எமிலி ஹென்டர்சன் , ஆரோன் ஸ்கிம்மர் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆரோக்கியம் வலைப்பின்னல் ,

Hibernating cancer cells may explain relapse after chemotherapy


Hibernating cancer cells may explain relapse after chemotherapy
Cancer seems to have hijacked a survival mechanism employed by hibernating animals during times of high stress.
The Himalayan black bears go in hibernation during winters. To survive this winter period, the bears need to eat and store fats before they go to hibernate. Credit: Wikimedia Commons.
Cancer is extremely tricky to get rid of. Even after a successful therapy that has seemingly extinguished a tumor, cancer can return unexpectedly years later. According to a new study, this happens as a result of cancer cells entering a dormant state that allows them to evade destruction from chemotherapy. The same cellular process is employed by some hibernating animals in nature. ....

Wikimedia Commons , Catherine Obrien , Aaron Schimmer , Princess Margaret Cancer Centre , University Of Toronto , Department Of Surgery , Catherineo Brien , Associate Professor , கேத்தரின் ஓபிறீேன் , ஆரோன் ஸ்கிம்மர் , ப்ரிந்ஸெஸ் மார்கரெட் புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , துறை ஆஃப் அறுவை சிகிச்சை , இணை ப்ரொஃபெஸர் ,