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Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response Researchers reporting on findings from the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial in the UK are recommending that any therapeutic use of REGEN-COV may be best restricted to individuals without detectable antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The RECVORY Collaborative Group says that among patients hospitalized with coronavirus disease 2019 (COVID-19), REGEN-COV reduced 28-day mortality by about one-fifth in those who were seronegative at baseline. REGEN-COV comprises two monoclonal antibodies (casirivimab and imdevimab) that bind to different epitopes on the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. The spike RBD mediates the initial stage of the infection process when it binds to the human host cell receptor angiotensin-converting enzyme 2. ....
Researchers at the U.S. Centers for Disease Control and Prevention (CDC) detected delayed and reduced antibody and T cell responses after immunization with BNT162b2 or the Pfizer-BioNTech COVID-19 vaccine in older adults compared with healthcare workers in Germany. ....
The study led by researchers from the New York University, US, showed that the Pfizer BNT162b2 vaccination worked well against the majority of variants as the earlier virus, but the vaccine neutralised the South African variant and the Brazil variant with a 3-fold decrease in titer. ....
The study led by researchers from the New York University, US, showed that the Pfizer BNT162b2 vaccination worked well against the majority of variants as the earlier virus, but the vaccine neutralised the South African variant and the Brazil variant with a 3-fold decrease in titer. ....