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Dublin-listed pharmaceutical services company Open Orphan has announced that its subsidiary hVivo has signed a £3 million contract to develop a âchallenge virusâ based on new emerging variants of Covid-19.
The contract is with Imperial College London as part of a Wellcome Trust-funded initiative to manufacture a SARS-CoV-2 challenge virus.
Under the agreement, hVivo will develop a new SARS-CoV-2 challenge virus based on new emerging variants of the virus, which will be used in future hVivo-run human challenge trials to allow direct comparisons of vaccines or antivirals against different Covid-19 variants.
In virus challenge studies, healthy volunteers are administered a pathogenic or virulent strain of virus.
It’s been over a year since my office shut down. Over a year since I went to a bar, a fitness class, a movie theater, a concert, a Knicks game, or to the many other public events that were once centerpieces of my social life.
But there’s finally,
finally a finish line in sight. There are three safe and effective COVID-19 vaccines authorized and available in the US and at least 90 percent of all adults will be eligible to receive one by April 19th. If our current vaccination pace continues, 75 percent of adults will have at least one dose by early summer. Reader, I am dying to get back to my favorite activities, and I can tell that people around me are, too.
The trial will involve up to 90 healthy adults aged 18–30 years who will be exposed to the original strain of the coronavirus in a safe, controlled environment to understand how the virus grows, as well as the early stages of infection before symptoms appear.
The challenge trial involves a consortium that includes researchers from
Imperial College London, Royal Free London NHS Foundation Trust, the government’s vaccines taskforce and the clinical company hVIVO.
Volunteers will be required to undergo extensive screening, which will include blood tests, imaging tests, heart scans and other physical examinations, to ensure they are not vulnerable to COVID-19. Volunteers will only be accepted if they have no history of COVID-19, no underlying health issues and no risk factors like smoking.
What trial volunteers should expect at Covid camp
Ahead of the world s first Covid-19 challenge trial, volunteers from flu trials say the main threat is one of sheer boredom
23 February 2021 • 11:03am
Sean Cousins, 30, has made more than £10,000 by taking part in medical trials in which he is deliberately infected with influenza. He hopes to be infected with Covid-19 in a trial later this year
Credit: Christopher Pledger
Sean Cousins was sitting with his laptop in his student bedroom in 2014 when he spotted a Facebook advert for a new medical trial marketing itself as “flu camp”. It was recruiting volunteers who were willing to be infected with a strain of influenza, to help scientists learn more about the virus. Keen for some time away from distractions to work on his final-year Japanese and Chinese thesis, he signed up.