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Study may lead to new therapies for patients suffering from Duchenne muscular dystrophy A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. Titled, A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression, the study was published today in Cell Reports. Chronic inflammation is a major pathological process contributing to the progression and severity of several degenerative disorders, including Duchenne muscular dystrophy (DMD). Studies directed at establishing a causal link between muscular dystrophy and muscle inflammation have revealed a complex dysregulation of the immune response to muscle damage. ....
A new study reveals how chronic inflammation promotes muscle fibrosis. The findings could lead to new therapies for people with Duchenne muscular dystrophy (DMD), a fatal muscle disease. Chronic inflammation is a major pathological process contributing to the progression and severity of several degenerative disorders, including Duchenne muscular dystrophy. Studies directed at establishing a causal link between muscular dystrophy and muscle inflammation have revealed a complex dysregulation of the immune response to muscle damage. During muscular dystrophy, chronic activation of innate immunity causes scarring of skeletal muscle, or fibrosis, which compromises motor function. How immunity is linked to the molecular and cellular regulation of muscle fibrosis was not well defined, until now. ....
E-Mail IMAGE: The analysis of dystrophic quadriceps by immunofluorescence microscopy highlights a novel interaction between immune cells and stromal progenitors that stimulates fibrosis during muscular dystrophy. Eosinophils are depicted in green, ILC2s. view more Credit: UCI School of Medicine Irvine, CA - April 14, 2021 - A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. Titled, A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression, the study was published today in ....
UCI receives $4.2 million grant to study sporadic inclusion body myositis affecting aging adults The National Institute of Arthritis and Musculoskeletal and Skin Diseases has awarded UCI a 5-year, $4.2 million grant to study sporadic inclusion body myositis (sIBM), which affects aging adults causing asymmetric muscle weakness and severe disability. The disease is currently untreatable and poorly understood. Led by principal investigator, Tahseen Mozaffar, MD, a professor of neurology and director of the Division of Neuromuscular Disorders and the UCI-MDA ALS and Neuromuscular Center at University of California Irvine s School of Medicine, the project aims to provide a detailed characterization of sIBM disease progression over a two-year period and explore biomarkers associated with the disease, along with their influence on disease behavior and progression. This study will be the largest of its kind, enrolling 150 subjects, with a planned two-year follow up, the longest du ....
E-Mail IMAGE: Tahseen Mozaffar, MD, a professor of neurology and director of the Division of Neuromuscular Disorders and the UCI-MDA ALS and Neuromuscular Center at UCI s School of Medicine will lead a. view more Credit: UCI School of Medicine Irvine, CA - April 6, 2021 - The National Institute of Arthritis and Musculoskeletal and Skin Diseases has awarded UCI a 5-year, $4.2 million grant to study sporadic inclusion body myositis (sIBM), which affects aging adults causing asymmetric muscle weakness and severe disability. The disease is currently untreatable and poorly understood. Led by principal investigator, Tahseen Mozaffar, MD, a professor of neurology and director of the Division of Neuromuscular Disorders and the UCI-MDA ALS and Neuromuscular Center at University of California Irvine s School of Medicine, the project aims to provide a detailed characterization of sIBM disease progression over a two-year period and explore biomarkers associated ....