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Three CU researchers recognized for contributions to immunotherapy in childhood cancer


Three CU researchers recognized for contributions to immunotherapy in childhood cancer
Three members of the University of Colorado Cancer Center and a longstanding supporter of the campus are part of a group of more than 200 researchers nationwide who were recognized in April with the Team Science Award from the American Association for Cancer Research (AACR).
The CU researchers Terry Fry, MD, Lia Gore, MD, and Amanda Winters, MD, PhD, all of whom practice at Children s Hospital Colorado, along with patient advocate Kevin Reidy are part of the St. Baldrick s Foundation Stand Up To Cancer Pediatric Cancer Dream Team, a group of some 200 researchers across 10 leading children s hospitals and childhood cancer-focused research programs who are helping to develop new immunotherapy approaches for high-risk childhood cancers. The collaboration has resulted in 319 peer-reviewed published manuscripts, 44 patent applications, the generation of more than $118 million in additiona ....

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Researchers identify a novel link between aging, metabolism and anti-cancer T-cell function


Researchers identify a novel link between aging, metabolism and anti-cancer T-cell function
MUSC Hollings Cancer Center researchers are finding solutions to the aging-related changes that reduce anti-cancer immunity. Besim Ogretmen, Ph.D., and colleagues found a novel link between aging, metabolism and anti-cancer T-cell function. Their work, published in
Cell Reports, sheds light on an important pathway that cannot be ignored during cancer treatment.
Two broad questions in cancer research are: How can cancer treatments be improved, and what is the link between cancer and aging?
We know that the protective T-cell response deteriorates with age. Mitochondrial function is now thought to be one of the central regulators of the aging process. Our experiments connected the dots with what was previously shown and highlighted some surprising and important pathways. ....

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