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A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers. They said a novel therapeutic drug combination - as well as testing for these mutations - may help address the disparity.
Hispanic and Latino children are between 1.2 and 1.75 times more likely to develop B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, than non-Hispanic and Latino children. They also have a 40% higher death rate than their counterparts after correcting for socioeconomic factors. Dr. Sinisa Dovat, a researcher and pediatric oncologist at Penn State Children s Hospital and Penn State Cancer Institute, partnered with Dr. Gordana Raca of Children s Hospital Los Angeles and Kimberly J. Payne of Loma Linda University to understand the biology behind this health disparity after prior research suggested that there may be an ....

Feng Yue , Yali Ding , Mark Reeves , Shriya Kane , Sinisa Dovat , Zissis Chroneos , Daniel Bogush , Joseph Schramm , Elanora Dovat , Los Angeles , Mary Mcgrath , Kimberlyj Payne , Hisham Abdel Azim , Dhimant Desai , Mario Soliman , Yiping Yang , Vladimir Spiegelman , Arati Sharma , Pavan Kumar Dhanyamraju , Arthur Berg , Jonathon Payne , Soumya Iyer , Gordana Raca , Deepa Bhojwani , Chandrika Gowda , Raghavendra Gowda ,