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PHILADELPHIA After a team of researchers showed that a certain enzyme's presence in cartilage increased significantly in people with osteoarthritis,. ....
Scientists discover new treatment target for osteoarthritis-like knee cartilage degeneration There is currently no cure for osteoarthritis, but a group of scientists believe they ve discovered a method through which a simple knee injection could potentially stop the disease s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that treating mice with surgery-inducedknee cartilage degeneration through the same pathway via the state of the art of nanomedicine could dramatically reduce the cartilage degeneration and knee pain. These findings were published in ....
E-Mail There is currently no cure for osteoarthritis, but a group of scientists believe they ve discovered a method through which a simple knee injection could potentially stop the disease s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that treating mice with surgery-inducedknee cartilage degeneration through the same pathway via the state of the art of nanomedicine could dramatically reduce the cartilage degeneration and knee pain. These findings were published in Science Translational Medicine. Our lab is one of the few in the world studying epidermal growth factor receptor (EGFR) signaling in cartilage and, from the beginning, we have found that EGFR deficiency or inactivation accelerates osteoarthritis progression in mice, said Ling Qin, PhD, an associate professor of Orthopaedic Surgery. Thus, we p ....