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Gene-blocking could be key to curbing obesity

It sounds too good to be true: blocking a gene linked to obesity to trigger a major reduction in body fat. While it’s not a reality for humans yet ....

Saqib Sachani , Frank Beier , Brent Wakefield , Silvia Penuela , University Of Toronto , Penuela Lab , Max Martin Western Communications , International Journal Of Obesity , Schulich School , Western Communications , International Journal ,

Target discovered that halts osteoarthritis-type knee cartilage degeneration


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There is currently no cure for osteoarthritis, but a group of scientists believe they ve discovered a method through which a simple knee injection could potentially stop the disease s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that treating mice with surgery-inducedknee cartilage degeneration through the same pathway via the state of the art of nanomedicine could dramatically reduce the cartilage degeneration and knee pain. These findings were published in
Science Translational Medicine.
Our lab is one of the few in the world studying epidermal growth factor receptor (EGFR) signaling in cartilage and, from the beginning, we have found that EGFR deficiency or inactivation accelerates osteoarthritis progression in mice, said Ling Qin, PhD, an associate professor of Orthopaedic Surgery. Thus, we p ....

United States , Wei Yu , Lin Han , Yulong Wei , Lijun Luo , Feifan Yu , L Scott Levin , Robertl Mauck , Lesan Yan , Biao Han , Jaimo Ahn , Charles Nelson , Zhiliang Cheng , Lutian Yao , Jessicaf Liu , Zengwu Shao , Jaym Patel , Leilei Zhong , Frank Beier , Andrew Tsourkas , National Institutes Of Health , University Of Michigan , Science Translational , Ling Qin , Penn Engineering , Penn Medicine ,