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Reverse engineering 3D chromosome models for individual cells


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IMAGE: A new computational technique that uses heat map data to reverse engineer highly detailed models of chromosomes and researchers have uncovered new information about the close spatial relationships that chromatin.
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Credit: UIC
Genome analysis can provide information on genes and their location on a strand of DNA, but such analysis reveals little about their spatial location in relation to one another within chromosomes the highly complex, three-dimensional structures that hold genetic information.
Chromosomes resemble a fuzzy X in microscopy images and can carry thousands of genes. They are formed when DNA winds around proteins called histones which are further folded into complexes called chromatin, which make up individual chromosomes. ....

United States , Qiu Sun , Jie Liang , Daniel Czajkowsky , Zhifeng Shao , Alan Perez Rathke , Shanghai Jiao Tong University , Nature Communications , University Of Illinois Chicago , National Institutes Of Health , National Key Research , Development Program Of China , Illinois Chicago , Loan Hill Professor , Development Program , National Institutes , Cell Biology , Medicine Health , Technology Engineering Computer Science , Gene Therapy , ஒன்றுபட்டது மாநிலங்களில் , கீயூ சூரியன் , ஜிே லியாங் , ஆலன் பெரெஸ் ரதிகெ , ஷாங்காய் ஜியாவோ நாக்கு பல்கலைக்கழகம் , இயற்கை தகவல்தொடர்புகள் ,