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Protein discovery could help prevent cancer t

Protein discovery could help prevent cancer t
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Zhaokang-cheng , Boyang-jason-wu , Jingrui-chen , Washington-state-university , National-institutes-of-health , National-cancer-institute , College-of-pharmacy , Blood-institute , National-heart , Method-of-research , Cardiovascular-research , Washington-state

Study identifies protein that could be the key to improving heart attack treatment outcomes


Study identifies protein that could be the key to improving heart attack treatment outcomes
A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack.
Published in the
Journal of Biological Chemistry, the research suggests that protein kinase A (PKA) plays a role in heart muscle cell necrosis, a major type of cell death that commonly occurs after reperfusion therapy, the treatment used to unblock arteries and restore blood flow after a heart attack.
Our study has found that turning off a gene that controls this protein activity increased necrotic cell death and led to more heart injury and worse heart function following heart attack in a rodent model. With further research, this discovery could ultimately lead to the development of a small-molecule drug that could intervene in that pathway to limit or prevent heart muscle cell death after reperfusion therapy. ....

Zhaokang-cheng , Emily-henderson , Washington-state-university , College-of-pharmacy , Biological-chemistry , Heart , Heart-attack , Protein , Ntioxidant , Lood , Ell , Ell-death

Target protein identified for improving heart attack treatment

A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack. Published in the Journal of Biological Chemistry, it suggests that protein kinase A (PKA) plays a role in heart muscle cell necrosis, a major type of cell death that commonly occurs after reperfusion therapy, the treatment used to unblock arteries and restore blood flow after a heart attack. ....

Constantine-stratakis , Jingrui-chen , Peng-xia , Yuening-liu , Zhaokang-cheng , Washington-state-university , Human-development , College-of-pharmacy , National-heart , Blood-institute , Biological-chemistry , Pharmaceutical-sciences