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The role of molecular interactions in cell differentiation and cancer invasion

This article outlines the role of molecular interactions in cell differentiation and cancer invasion. ....

United Kingdom , Zeiss Axioobserver , Bruker Bioafmdec , Nanowizard Hybridstage , Bruker Bio , Humboldt University Berlin , Fuhs University Leipzig , University Of Sheffield , Sponsored Content , Image Credit , University Leipzig , Probe Microsc , Drug Delivery Systems , Hindawi Publishing , Scientific World Journal , Nic Mullin , Content Policy , News Medical Net , Molecular Interactions ,

Identification of an Altered Matrix Signature in Kidney Aging and Disease

Identification of an Altered Matrix Signature in Kidney Aging and Disease
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United Kingdom , United States , Aleksandr Mironov , Zeiss Axioimager , David Knight , Zeiss Axioobserver , Zeiss Axiovision , Stacey Warwood , Axiocam Mrm , T Van Agtmael , Julian Selley , Research Council Genetically Engineered Mice For Medicine , Janssen Biotech Inc , Faculty Of Life Sciences , Kidney Research United Kingdom Strategy Committee , Thermo Fisher , Proteomexchange Consortium , University Of Manchester Strategic Fund , Progenesis Nonlinear Dynamics Ltd , Extracellular Matrix Remodeling In Kidney Health , Graphpad Software , United Kingdom Renal Fibrosis Network , University Of Kansas Medical Center , Kidney International , University Of Manchester , Sciences Research Council ,

Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione

P2RY8 is a G protein–coupled receptor (GPCR) that is involved in restraining germinal center (GC) B cell migration and growth. It is unclear how the ligand of P2RY8, S -geranylgeranyl-l-glutathione (GGG), is involved in these processes. Using gain-of-function mouse models and genetically modified human T cells, Gallman et al. showed that expression of gamma-glutamyltransferase-5 (Ggt5) on stromal cells and ATP-binding cassette subfamily C member 1 (Abcc1) on hematopoietic cells was involved in catabolizing and transporting GGG, respectively, and restraining P2RY8+ cells within GCs. GGG and P2RY8 interactions also restrained lymphocyte trafficking to the bone marrow. Thus, GGG and P2RY8 processing and interactions are crucial for the confinement of B cells within GCs and for inhibiting migration of lymphocytes into bone marrow.

P2RY8 promotes the confinement and growth regulation of germinal center (GC) B cells, and loss of human P2RY8 is associated with B cell lymphomagenesis. ....

United States , Zeiss Axioobserver , Sjl Ptprcapepcb Boycrcrl , National Cancer Institute At Charles River , Laboratory Animal Resource Center , Colorado Serum Company , National Cancer Institute , Charles River , Institutional Animal Care , Thermo Fisher Scientific , Life Technologies , Cayman Chemical , ஒன்றுபட்டது மாநிலங்களில் , ஆய்வகம் விலங்கு வள மையம் , கொலராடோ சீரம் நிறுவனம் , தேசிய புற்றுநோய் நிறுவனம் , சார்லஸ் நதி , நிறுவன விலங்கு பராமரிப்பு , தெர்மோ மீனவர் அறிவியல் , வாழ்க்கை தொழில்நுட்பங்கள் , கேமன் இரசாயன ,