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Early identification of illnesses like dementia and cancer, before they cause severe, irreversible symptoms, is crucial for public health and can lower morbidity and death rates. ....
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Credit: by Shui-Jing Tang, Paul H. Dannenberg, Andreas C. Liapis, Nicola Martino, Yue Zhuo, Yun-Feng Xiao, and Seok-Hyun Yun Laser particles are micrometre and nanometre lasers in the form of particles dispersible in aqueous solution, which have attracted considerable interest in the life sciences as a promising new optical probe. Laser particles emit highly bright light with extremely narrow spectral bandwidth. By transferring laser particles into live cells as shown in Figure 1, individual cells in a heterogeneous population can be tracked using each intracellular particle s specific spectral fingerprint as an optically readable barcode. However, laser particles emit directional light (Figure 2) and freely tumble inside living cells, their orientation varying randomly over time. Therefore optical readout of these labels results in lighthouse-like blinking, leading to frequent loss of cell traces. ....