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United States , Quan Shi , Yu Wang , Shan Jiang , Shui Tang , Xi Yang , Zhuo Xu , Xiaoj Chen , Janete Buchino , Wenmin Luo , Ali Aydin , Johns Lowton , Daniel Tetzaguic , Davidj Begonis , Nidhi Bhagria , Floramef Rogeski , Dana Cho , Ching Margaret , Christopherm Fauteux , Giuseppee Onorati , Meredith Agnew , James Watson , Laurene Dore , Jenniferr Arruda , Anurag Banerjee , Marjorie Bradford ,

Researchers Identify a Regulator of Breast Cancer Development

UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common typ ....

United States , Yuanyuan Xue , Ryan Chen , Chao Xing , Bo Zhang , Ashwani Kumar , Jeffreyg Mcdonald , Yingfei Wang , Maowu Luo , Chenliang Wang , Weibo Luo , Jennifer Wang , Yisheng Fang , Yong Wang , Lisa Dean Moseley Foundation , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , Mary Kay Foundation , Research Institute Of Texas , American Cancer Society , Science Advances , Associate Professor , Comprehensive Cancer , Lei Bao , Cancer Prevention , Research Institute ,

Researchers identify potential therapeutic target to prevent neurodegeneration after a stroke

Researchers identify potential therapeutic target to prevent neurodegeneration after a stroke
Researchers with the Peter O Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke.
Scientists from the departments of pathology, neurology, biochemistry, and pharmacology at UTSW have identified and named AIF3, an alternate form of the apoptosis-inducing factor (AIF), a protein that is critical for maintaining normal mitochondrial function. Once released from mitochondria, AIF triggers processes that induce a type of programmed cell death. ....

Yingfei Wang , Peter Odonnell Jr , Emily Henderson , Centers For Disease , Odonnell Brain Institute , Brain Institute , Johns Hopkins University School Of Medicine , Petero Donnell , Molecular Neurodegeneration , Johns Hopkins University School , O Donnell Brain , Disease Control , Ell Death , Neurodegenerative Diseases , Programmed Cell Death , பீட்டர் ஓடொன்னேழில் ஜூனியர் , எமிலி ஹென்டர்சன் , மையங்கள் க்கு நோய் , ஓடொன்னேழில் மூளை நிறுவனம் , மூளை நிறுவனம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி , ஓ டோனெல் மூளை , நோய் கட்டுப்பாடு ,

Researchers identify protein produced after stroke that triggers neurodegeneration

UT Southwestern Medical Center
April 27, 2021 – Researchers with the Peter O’Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke.
Scientists from the departments of pathology, neurology, biochemistry, and pharmacology at UTSW have identified and named AIF3, an alternate form of the apoptosis-inducing factor (AIF), a protein that is critical for maintaining normal mitochondrial function. Once released from mitochondria, AIF triggers processes that induce a type of programmed cell death.
In a study published in the journal Molecular Neurodegeneration, the UT Southwestern team collaborated with researchers at The Johns Hopkins University School of Medicine and found that, following a stroke, the brain switches from producing AIF to producing AIF3. They also reported that stroke triggers ....

Yingfei Wang , Peter Odonnell Jr , Centers For Disease , Odonnell Brain Institute , Brain Institute , Johns Hopkins University School Of Medicine , Petero Donnell , Molecular Neurodegeneration , Johns Hopkins University School , O Donnell Brain , Disease Control , பீட்டர் ஓடொன்னேழில் ஜூனியர் , மையங்கள் க்கு நோய் , ஓடொன்னேழில் மூளை நிறுவனம் , மூளை நிறுவனம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி , ஓ டோனெல் மூளை , நோய் கட்டுப்பாடு ,