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METTL3 Controls Splicing Factor Abundance and Aids Progression in CLL

Yiming Wu, PhD, discusses the rationale for studying splicing defects in patients with chronic lymphocytic leukemia without spliceosome mutations, shared key findings from this study, and emphasized how these findings support further research with METTL3 in chronic lymphocytic leukemia and other hematologic malignancies with RNA splicing dysregulation.
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United States , Yiming Wu , Systems Biology , City Of Hope , Chronic Lymphocytic Leukemia ,

Dr Wu on the Role of METTL3-Mediated m6A Modification in CLL Progression

Yiming Wu, PhD, discusses a study identifying METTL3-mediated N6-methyladenosine modification as a key translational regulator of splicing factors, and how this mechanism contributes to the progression of chronic lymphocytic leukemia.
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Yiming Wu , Department Of Systems Biology , Systems Biology , Chronic Lymphocytic Leukemia , Onclive Tv , Moffitt Cancer Center ,