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Non-hallucinogenic psychedelic analog reverses effects of stress in mouse study


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IMAGE: A single dose of tabernanthalog (TBG) promotes the formation of dendritic spines in cortical neurons of mice.
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Credit: Illustration by Chelsea Kintz
A novel compound similar in structure to the psychedelic drug ibogaine, but lacking its toxic and hallucinogenic effects, has been found to rapidly reverse the effects of stress in mice.
Researchers found that a single dose of tabernanthalog (TBG) can correct stress-induced behavioral deficits, including anxiety and cognitive inflexibility, and also promotes the regrowth of neuronal connections and restores neural circuits in the brain that are disrupted by stress. The study was published May 25 in ....

Michelle Tjia , Kacper Lukasiewicz , Sajita Shah Morales , Bing Cao , David Olson , Ju Lu , Lindsay Cameron , Brian Mullen , Yi Zuo , Lu Chen At Stanford University , National Institutes Of Health , Max Planck Society , Institutional Animal Care , Use Committees Remain , Sydney Weiser , Stanford University , National Institutes , Max Planck , Medicine Health , Pharmaceutical Science , Mental Health , Stress Anxiety , பிங் சாவ் , டேவிட் ஓல்சன் , ஜூ லு , லிண்ட்சே கேமரூன் ,

Psychedelic compounds have shown the ability to drastically reduce stress in mice, study finds


This gives new meaning to the phrase, take a chill pill.
Researchers at UC Santa Cruz have found that a non-hallucinogenic psychedelic similar to the psychoactive substance ibogaine drastically lowers the levels of stress in mice.
A single dose of tabernanthalog (TBG) can lower anxiety and cognitive inflexibility in the rodents.
It also has the ability to promote the regrowth of neuronal connections and restoring neural circuits that are negatively impacted from stress. 
It was very surprising that a single treatment with a low dose had such dramatic effects within a day, said one of the study s co-authors Yi Zuo, professor of molecular, cell, and developmental biology at UC Santa Cruz, in a statement.  ....

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Non-hallucinogenic psychedelic analog reverses effects of stress in mouse study

Non-hallucinogenic psychedelic analog reverses effects of stress in mouse study
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