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Novel approach to interrogate tissue-specific protein-protein interactions

Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing. ....

Xiang David Li , Li Ka Shing , Xiang David , Chaogu Zheng , School Of Biomedical Sciences , Proceedings Of The National Academy Sciences , Department Of Chemistry , School Of Biological Sciences , University Of Hong Kong , Hong Kong , Professor Xiang David , Professor Chaogu , Biological Sciences , Biomedical Sciences , Methionine Analog Based Cell Specific Proteomics , National Academy ,

Scientists develop novel approach to interrogate tissue-specific protein–protein interactions

Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. ....

Xiang David Li , Chaogu Zheng , Siyue Huang , Xiucong Bao , Li Ka Shing , Department Of Chemistry , Proceedings Of The National Academy Sciences , School Of Biological Sciences , University Of Hong Kong , School Of Biomedical Sciences , National Academy , Hong Kong , Professor Chaogu Zheng , Biological Sciences , Biomedical Sciences , Methionine Analog Based Cell Specific Proteomics , Professor Xiang David , Professor Chaogu ,

HKU research advances understanding of the fundamental biological processes of gene regulation

A research team from the University of Hong Kong led by Professor Xiang David Li from the Department of Chemistry in collaboration with Dr Yuanliang Zhai from the HKU School of Biological Sciences and Dr Jason Wing Hon Wong and Dr Xiucong Bao from the HKU School of Biomedical Sciences recently made a key breakthrough in understanding how genetic information encoded in our DNA is 'read' and why errors in 'reading' such information can often lead to developmental defects or cancers. ....

Xiang David Li , Yuanliang Zhai , Xiucong Bao , Emily Henderson , School Of Biological Sciences , Cancer Research , Cancer Research Industry , Department Of Chemistry , School Of Biomedical Sciences , University Of Hong Kong , Hong Kong , Biological Sciences , Biomedical Sciences , Research Industry Focus , Genetic Information ,