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Until we stop treating cancer as a 'family doctor' disease, our rates will never improve

A new study on missed ‘red flags’ in GP diagnoses means we need to rethink things urgently to save more lives ....

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'Patchwork' tumors prevalent across multiple cancer types

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Researchers at the Francis Crick Institute, as part of an international collaboration of scientists through the Pan-Cancer Analysis of Whole Genomes Consortium, have analysed the whole genomes of tumour samples from over 2,600 patients with different types of cancer. They identified a high prevalence of genetic diversity within individual tumours, which they further characterised. Their findings confirm that, even at late stages of development, tumour evolution is driven by changes that benefit the cancer.
When cancer cells divide, errors occur in the process of copying their DNA. These copying errors mean that different tumours can be made up of cells presenting a wide range of genetic diversity. This variation is a challenge for doctors as a treatment that works for one group of genetically related tumour cells, called a subclone, may not be effective against another. And certain subclones can initiate tumour spread or drug resistance. ....

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Genetic diversity within tumors suggests continuous evolution

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Genetic diversity within tumors suggests continuous evolution
By analyzing tumors from more than 2,600 patients and from 38 cancer types, researchers from The University of Texas MD Anderson Cancer Center and fellow member institutions of the international Pan-Cancer Analysis of Whole Genomes Consortium have characterized the extensive genetic diversity across cancer and within individual tumors.
The study, published today in Cell, found that 95% of the analyzed tumors had at least one subclone, or genetically distinct group of tumor cells, and these subclones were often very diverse – even in the same tumor. The findings suggest that tumors continue to evolve in ways that help the cancer survive. ....

New York , United States , Memorial Sloan Kettering Cancer Center , United Kingdom , Quaidd Morris , Wenyi Wang , University Of Texas Md Anderson Cancer Center , University Of Oxford , Md Anderson Moon Shots Program , Cancer Analysis Of Whole Genomes Consortium , University Of Toronto , Cancer Genomics Laboratory , Francis Crick Institute , Cancer Center , Pan Cancer Analysis , Whole Genomes Consortium , Peter Van Loo , Francis Crick , Moon Shots Program , Ivan Loo , New York City , Whole Genomes , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , நினைவகம் ஸ்லோன் கெட்டரிங் புற்றுநோய் மையம் , ஒன்றுபட்டது கிஂக்டம் ,