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Cardiovascular risk associated with social determinants of health at individual and area levels 1. In this cohort study, individual and area level social determinants of health (SDOH) were associated with an increased risk in atherosclerotic cardiovascular disease (ASCVD) events. Evidence Rating Level: 1 (Excellent) Social determinants of health (SDOH) are several conditions that affect people’s ....
Efficacy and safety of sitagliptin with basal-plus insulin regimen versus insulin alone in non-critically ill hospitalized patients with type 2 diabetes: SITA-PLUS hospital trial 2. Patients randomized to receive and addition of sitagliptin to insulin therapy provided non-critically ill hospitalized patients with type 2 diabetes (T2DM) better glycemic control and higher mean daily glucose level ....
Sarcopenia and Sarcopenic Obesity and Mortality Among Older People 1. In this secondary analysis of the Rotterdam study, older adults with sarcopenia and sarcopenic obesity (SO) were at significantly higher risk for all-cause mortality than their non-SO counterparts. Evidence Rating Level: 2 (Good) Sarcopenia, or low skeletal muscle mass and strength, is a phenotype of ....
Concomitant Use of Selective Serotonin Reuptake Inhibitors With Oral Anticoagulants and Risk of Major Bleeding 1. This case-control study found that in patients with atrial fibrillation concomitant Serotonin Reuptake Inhibitor (SSRI) and Oral Anticoagulants (OAC) was associated with an increased risk of major bleeding compared with OAC use alone. 2. This increased risk was highest ....
Early vs Late Fixation of Extremity Fractures Among Adults With Traumatic Brain Injury 1. In a cohort of patients with traumatic brain injury, early fixation of extremity fractures within 24 hours of injury was not associated with greater rates of unfavourable functional outcomes at 6 months. Evidence Rating: 2 (Good) While extremity fractures are commonly ....