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Cardiovascular risk associated with social determinants of health at individual and area levels 1. In this cohort study, individual and area level social determinants of health (SDOH) were associated with an increased risk in atherosclerotic cardiovascular disease (ASCVD) events. Evidence Rating Level: 1 (Excellent) Social determinants of health (SDOH) are several conditions that affect people’s ....

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Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study

Objective To determine whether the combined use of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors is associated with a decreased risk of major adverse cardiovascular events and serious renal events compared with either drug class alone among patients with type 2 diabetes, and to assess the effect of the combination on the individual components of major adverse cardiovascular events, heart failure, and all cause mortality.

Design Population based cohort study using a prevalent new-user design, emulating a trial.

Setting UK Clinical Practice Research Datalink linked to Hospital Episode Statistics Admitted Patient Care and Office for National Statistics databases.

Participants Two prevalent new-user cohorts were assembled between January 2013 and December 2020, with follow-up until the end of March 2021. The first cohort included 6696 patients who started GLP-1 receptor agonists and added on SGLT-2 inhibitors, ....

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Concomitant Use of SSRIs and Oral Anticoagulants Increases Major Bleeding Risk

SSRIs increase major bleeding risk by about 33% for patients with atrial fibrillation who are also using oral anticoagulants. ....

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Concomitant Use of SSRIs and Oral Anticoagulants Increases Major Bleeding Risk

SSRIs increase major bleeding risk by about 33% for patients with atrial fibrillation who are also using oral anticoagulants. ....

United Kingdom , Noacs Doacs , United Kingdom Clinical Practice Research Datalink , International Classification Of Diseases , International Classification , Tenth Revision ,