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Photo Credit: Hannes Alessandrini) As MitraClip procedures continue to expand as an option for nonsurgical patients with functional or degenerative mitral regurgitation (MR), a new question will increasingly arise: what’s the best approach for treating patients whose clip procedures fail? Now, a small, retrospective, single-center study is trying to shed some light. As Hannes Alessandrini, MD (Asklepios Klinik St. Georg, Hamburg, Germany), and colleagues write in EuroIntervention this month, the best approach may depend on the source of mitral valve dysfunction in the first place. “There are two conclusions that we have reached,” Alessandrini told TCTMD. “The first is that we have less concern about considering a surgical intervention after transcatheter mitral valve repair in patients with primary mitral regurgitation. . . . And the second is that we also have less concern about performing a second intervention with the edge-to-edge therapy in patients wh ....