New research finds an unexpected link between chromosomal instability and epigenetic alternations, both of which are hallmarks of cancer especially advanced, drug-resistant cancers.
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Tiny circles of DNA that defy the accepted laws of genetics are key drivers of cancer formation, according to an international study led by researchers at Stanford Medicine.The circles, known as extrachromosomal DNA or ecDNA, often harbor cancer-asso
Extrachromosomal circular DNA has been linked with the growth of tumors due to their resistance to treatment and poorer patient outcomes, according to a study published in Nature. Postdoctoral researcher Jens Luebeck at the computer science department and co-author of the paper explained that the study looked at patients with Barrett’s esophagus, a precancerous.