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welcome to the programme. since donald trump left office, he has been in a seemingly endless web of investigations and legal cases. alongside the investigations into his role in the january 6th riots and attempts to overturn the election, there is also an ongoing criminal probe into the trump organization for tax and bank fraud allegations. and today, the heat was turned up in that case. the company s former chief financial officer allen weisselberg plead guilty to conspiring with the company in a years long tax fraud scheme. he will now go to jail forfive months. the concern for donald trump is that as part of a plea deal, the as part of a plea deal, concern for donald trump as of the concern for donald trump as part of this plea deal allen weisselberg has agreed to testify in the upcoming trial against the trump organisation. let s go through some of what is going on here. our correspondent nada tawfik is following things in new york. allen weisselberg has agreed this ....
The loss of inner ear hair cells causes permanent hearing and balance deficits in humans and other mammals, but nonmammals recover after supporting cells (SCs) divide and replace hair cells. The proliferative capacity of mammalian SCs declines as exceptionally thick circumferential F-actin bands develop at their adherens junctions. We hypothesized that the reinforced junctions were limiting regenerative responses of mammalian SCs by impeding changes in cell shape and epithelial tension. Using micropipette aspiration and atomic force microscopy, we measured mechanical properties of utricles from mice and chickens. Our data show that the epithelial surface of the mouse utricle stiffens significantly during postnatal maturation. This stiffening correlates with and is dependent on the postnatal accumulation of F-actin and the cross-linker Alpha-Actinin-4 at SC-SC junctions. In chicken utricles, where SCs lack junctional reinforcement, the epithelial surface remains compliant. There, SCs un ....