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TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders

TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Bioanalyzer Agilent , Novocyte Quanteon , Graphpad Software Inc , Jackson Laboratory , Tree Star Inc , Ghent University , Abbott Laboratories , Spike Epitope , Spike Tetramer , Cell Tracer Violet , Representative Flowjo , Janvier Labs , Cell Isolation Kit , Cell Proliferation Dye , Thermo Fisher Scientific , European Virus Archive , Biosafety Level , Beads Counting , Tree Star , Graphpad Prism , Graphpad Software , Core Facility , Chromium Gemcode Single Cell Instrument , Gemcode Single Cell , Gel Bead , Illumina Novaseq ,

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1–AMPK–ACC Pathway

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1–AMPK–ACC Pathway
nih.gov - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nih.gov Daily Mail and Mail on Sunday newspapers.

United States , Ted Pella , Tree Star Inc , Committee Of Nanjing Medical University , Cell Signaling Technology , Jiangsu Provincial Key Laboratory Of Geriatrics , Carl Zeiss , Laboratory Animal Center Shanghai , Global Cancer Epidemiological , National Natural Science Foundation Of China , Global Cancer Epidemiological Survey , Jiangsu Provincial Key Laboratory , Key Laboratory , Antibody Technique , National Health Commission , Nanjing Medical University , Shanghai Biowing Biotechnology Application , Thermo Fisher Scientific , Institutional Animal Care , Use Committee , Animal Center , Electron Microscopy , Glutathione Reductase Assay Kit , Lipid Peroxidation , Ferrogreen Labeled Immunofluorescence Assay , Jingmei Biotechnology ,

An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs | Virology Journal

Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV). Although effective vaccines have long existed, current vaccines take both time and cost to produce. Messenger RNA (mRNA) technology is an emergent vaccine platform that supports rapid vaccine development on a large scale. Here, an optimized mRNA vaccine construct (LVRNA001) expressing rabies virus glycoprotein (RABV-G) was developed in vitro and then evaluated in vivo for its immunogenicity and protective capacity in mice and dogs. LVRNA001 induced neutralizing antibody production and a strong Th1 cellular immune response in mice. In both mice and dogs, LVRNA001 provided protection against challenge with 50-fold lethal dose 50 (LD50) of RABV. With regards to protective efficiency, an extended dosing interval (14 days) induced greater antibody production than 3- or 7-day intervals in mice. Finally, post-exposure immunization against RABV was performed to evaluate the survival rates of dogs rec ....

United States , San Diego , Baden Wüberg , Neo Bioscience , Institute Of Military Veterinary Medicine , Tree Star Inc , Guangdong Academy Of Agricultural Sciences , Institute Of Animal Health , Synbiotics Corp , Dnasei Novoprotein Scientific Inc , Sepax Technologies Inc , Research Ethics Committee Of The College , Academy Of Military Medical Sciences Changchun , G Jiangsu Synthgene Biotechnology Co , Repligen Corporation , World Organization For Animal Health , Guangdong Academy Of Agricultural Sciences Guangzhou , Boehringer Ingelheim Vetmedica Inc , Novoprotein Scientific Inc , Chinese National Institutes For Food , Academy Of Military Medical Sciences , Hytest Ltd , Animal Health , Guangdong Academy , Agricultural Sciences , Military Veterinary Medicine ,

Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization | Parasites & Vectors

Inflammatory bowel disease (IBD) is a chronic idiopathic disease characterized by inflammation-related epithelial barrier damage in the intestinal tract. Helminth infection reduces autoimmune disease symptoms through regulation of inflammatory responses based on hygiene theory. However, the underlying mechanisms remain unclear. BALB/c mice were infected with microcysts of E. granulosus sensu stricto and drank water containing 3.5% dextran sodium sulfate (DSS) at the 100th day post-infection. After 7 days of drinking DSS, the mouse body weight change and disease activity index (DAI) were recorded every day, and colon length and histological score were evaluated after sacrifice. After injection with antigen B (AgB), inducible nitric oxide synthase (iNOS) and Fizz1 expression and F4/80+CD11c+ M1 and F4/80+CD206+ M2 in the peritoneal cells and colon tissues were analysed by qPCR and flow cytometry, respectively. Gut microbiota were profiled by 16S rRNA sequencing of the mouse faec ....

United States , Tree Star Inc , Graphpad Software Inc , First Affiliated Hospital Of Xinjiang Medical University , Jiancheng Bioengineering Institute , Genscript Biotech Corp , Roswell Park Memorial Institute , Takara Bio Inc , Vital River Laboratory Animal Technology Co Ltd , Xinjiang Uyghur Autonomous Region , First Affiliated Hospital , Xinjiang Medical University , Endotoxin Removal Kit , Gel Clot Endotoxin Assay Kit , San Jose , Flow Cytometer , Tree Star , San Carlos , Shanghai Institutes , Cell Biology , Nanjing Jiancheng Bioengineering Institute , Takara Bio , Mini Kit , Transstart Fastpfu , Illumina Miseq , Graphpad Prism ,

Gut and cutaneous microbiome featuring abundance

Revealing causal role of gut microbiota dysbiosis in psoriasis pathogenesis and investigating protective effect of healthy commensal bacteria against imiquimod ....

Eteläuomen Läi , United States , Bacteroidetes Firmicutes , Tree Star Inc , Ethics Committee Of Minhang Hospital , Dna Eraser Takara Biotech Co , Ac Association , Lactobacillus Administration , Fudan University , Vital River Laboratory Animal Technology Co Ltd , Beckman Coulter , Yaodan Biotechnology Co Ltd Shanghai , Ethical Committee Of Minhang Hospital , Ethics Committee , Minhang Hospital , Sichuan Medshine Pharmaceutical , Psoriasis Area , Severity Index , Ethical Committee , Illumina Miseq , Ionomycin Mixture , Monensin Mixture , Tree Star , Microplate Readers , Shannon Index , Digimatic Caliper ,