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Research finds VISTA directly blocks T-cells from functioning in immunotherapy

A team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment. The study explains that VISTA can bind to a protein called LRIG1 in T cells, which was previously only thought to promote bone and fat development. When VISTA binds to LRIG1, the researchers found, LRIG1 sends signals that suppress T cell replication, survival and function. This interaction can happen between molecules on tumor cells and on T cells, molecules on healthy cells and T cells and even between molecules on the same T cell.

Keman zhangTyler albanBrian gastmanTimothy chanLi lily wangSheikha fatimaStefanie avrilCleveland clinic centerCase western reserve universityGlobal centerScience immunologyCleveland clinicTranslational hematologyPrecision immuno oncologyMubarak endowed chairDia roy

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.

Sheikha fatimaLi lily wangKeman zhangTimothy chanBrian gastmanStefanie avrilTyler albanGlobal centerCleveland clinic centerCase western reserve universityCleveland clinic ledScience immunologyCleveland clinicTranslational hematologyPrecision immuno oncologyMubarak endowed chair

Research finds the protein VISTA directly blocks T cells from functioning in immunotherapy

Research finds the protein VISTA directly blocks T cells from functioning in immunotherapy
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Li lily wangTyler albanKeman zhangBrian gastmanTimothy chanSheikha fatimaStefanie avrilCase western reserve universityGlobal centerCleveland clinic centerCleveland clinic ledScience immunologyCleveland clinicTranslational hematologyPrecision immuno oncologyMubarak endowed chair

AI Model Prescribes Best Drug Combinations for Bacterial Infections

Researchers at Cleveland Clinic have created an artificial intelligence (AI) model capable of identifying the optimal combination and timing for prescribing drugs to combat bacterial infections, relying solely on the rate of bacterial growth under specific conditions. The findings were published in PNAS.

Jeff maltasJacob scottTheory division of translational hematologyTranslational hematology oncology researchCleveland clinicTheory divisionTranslational hematologyStudy first authorMedical studentPostdoctoral fellow

AI Can Develop Superbug Treatments, Cleveland Clinic Study Finds

AI Can Develop Superbug Treatments, Cleveland Clinic Study Finds
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Jacob scottJeff maltasTheory division of translational hematologyCleveland clinicTheory divisionTranslational hematologyDavis weaver