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How to understand chronic pain

How to understand chronic pain ....

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Used, reused or euthanized: A dog's life in animal research

A lab that conducts studies for a San Diego-based pharmaceutical company is facing scrutiny over its use of beagles. ....

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Part 2: Beagles in drug trials

A look into the current state of science and regulations when it comes to using animals in research. In other news, San Diego County health officials held a monkeypox town hall yesterday, to discuss the virus with community members. Plus, some of the weekend arts events happening around San Diego. ....

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Normalizing cholesterol metabolism in microglia alleviates chronic neuropathic pain

Normalizing cholesterol metabolism in microglia alleviates chronic neuropathic pain
Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.
The findings are published in the May 10, 2021, online issue of the
Journal of Experimental Medicine.
The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuro inflammation. Yaksh specializes in neuropathic pain. ....

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Cholesterol Control Could Reduce Chronic Pain After Chemotherapy

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Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.
The findings are published in the May 10, 2021, online issue of the Journal of Experimental Medicine.
The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuro inflammation. Yaksh specializes in neuropathic pain. ....

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