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Two Hundred Approved Drugs Found to be Effective Against COVID-19

Two Hundred Approved Drugs Found to be Effective Against COVID-19
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Tony Kouzarides , Professor Tony Kouzarides ,

New class of compounds found to block coronavirus reproduction


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A human genetic mechanism hijacked by SARS-CoV-2, the coronavirus behind the COVID-19 pandemic, to help it spread also makes it vulnerable to a new class of drug candidates, a new study finds.
Led by researchers at NYU Grossman School of Medicine, a research team showed that coronavirus reproduction in infected human cells requires chemical changes made by the human protein METTL3 to RNA, a key form of genetic material. Additional human proteins involved in the recognition of modified RNA, YTHDF1 and YTHDF3, were also found to be important to the process.
Published online in
Genes and Development on June 24, the study showed for the first time that a molecular inhibitor of METTL3, designed by Storm Therapeutics Ltd and called STM2457, dramatically reduced in cell cultures the replication of both pandemic SARS-CoV-2 and, a less severe, seasonal coronavirus, HCoV-OC43, one cause of the common cold. ....

United Kingdom , Hannah Burgess , Tony Kouzarides , Kenneth Stapleford , Rebecca Grande , Angus Wilson , Wesley Blackaby , Daniel Depledge , Alan Hendrick , Elizabeth Vink , Puthankalam Srinivas Kalanghad , Jonathan Abebe , Ian Mohr , Letitia Thompson , Langone Health , National Institute Of Allergy , National Institutes Of Health , Perlmutter Cancer Center Support Grant , Gurdon Institute , University Of Cambridge , Department Of Microbiology , Grossman School Of Medicine , Storm Therapeutics Ltd , Department Of Pathology , Department Of Medicine , Mark Albertella At Storm Therapeutics Ltd ,