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Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial

Sotorasib significantly increased progression-free survival and had a more favourable
safety profile, compared with docetaxel, in patients with advanced NSCLC with the
KRASG12C mutation and who had been previously treated with other anticancer drugs. ....

Small Cell Lung Cancer Study Group , Clin Oncol , Treat Options Oncol , Small Cell Lung Cancer Study , Related Quality , Thorac Oncol , Lung Cancer , Cancer Res , Englj Med , Scare Cancer ,

Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study

These updated, long-term data from CROWN show the durable benefit of lorlatinib over
crizotinib in patients with treatment-naive, ALK-positive non-small-cell lung cancer
and support the use of first-line lorlatinib in patients with and without baseline
brain metastases. ....

Drug Administration , European Medicines Agency , Englj Med , Cancer Res , Med Chem , Clin Oncol , Thorac Oncol , Med Econ ,

European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission

Cancer research is a crucial pillar for countries to deliver more affordable, higher
quality, and more equitable cancer care. Patients treated in research-active hospitals
have better outcomes than patients who are not treated in these settings. However,
cancer in Europe is at a crossroads. Cancer was already a leading cause of premature
death before the COVID-19 pandemic, and the disastrous effects of the pandemic on
early diagnosis and treatment will probably set back cancer outcomes in Europe by
almost a decade. ....

United Kingdom , United States , Le Chatelier , Champagne Ardenne , Nord Pas De Calais , Krasnoyarskiy Kray , Permskiy Kray , New York , White House , District Of Columbia , Good Friday , New South Wales , Le Chevalier , Provence Alpes Côd Azur , Noord Brabant , L Vivs Ka Oblast , World Bank , Russian Federation , Molina Barcel , Van Hemelrijck , Murphy Jr , Carnall Farrar , Gastroenterol Hepatol , International Standard Of Quality Cancer Care , International Cancer Research Partnership , Eurj Health Econ ,