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Pembrolizumab Plus Lenvatinib Misses Both Survival End Points in Advanced, Recurrent Endometrial Cancer

The combination of pembrolizumab and lenvatinib failed to produce a statistically significant improvement in progression-free survival and overall survival vs platinum-based chemotherapy with carboplatin and paclitaxel as frontline therapy in patients with advanced or recurrent endometrial cancer whose disease in mismatch repair proficient/not microsatellite instability–high or mismatch repair deficient. ....

Gregory Lubiniecki , Corina Dutcus , Merck Research Laboratories , Global Clinical Development , Oncology Global Clinical Development Lead , Eisai Inc , Gynecologic Oncology , The Phase 3 Leap 001 Trial ,