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Pembrolizumab Plus Lenvatinib Misses Both Survival End Points in Advanced, Recurrent Endometrial Cancer

The combination of pembrolizumab and lenvatinib failed to produce a statistically significant improvement in progression-free survival and overall survival vs platinum-based chemotherapy with carboplatin and paclitaxel as frontline therapy in patients with advanced or recurrent endometrial cancer whose disease in mismatch repair proficient/not microsatellite instability–high or mismatch repair deficient. ....

Gregory Lubiniecki , Corina Dutcus , Merck Research Laboratories , Global Clinical Development , Oncology Global Clinical Development Lead , Eisai Inc , Gynecologic Oncology , The Phase 3 Leap 001 Trial ,

Eisai and Merck & Co., Inc., Rahway, NJ, USA Provide Update on Phase 3 LEAP-001 Trial Evaluating LENVIMA (lenvatinib) Plus KEYTRUDA (pembrolizumab) as First-Line Treatment for Patients with Advanced or Recurrent Endometrial Carcinoma

Eisai and Merck & Co., Inc., Rahway, NJ, USA Provide Update on Phase 3 LEAP-001 Trial Evaluating LENVIMA (lenvatinib) Plus KEYTRUDA (pembrolizumab) as First-Line Treatment for Patients with Advanced or Recurrent Endometrial Carcinoma
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United States , Damini Chokshi , Julie Cunningham , Peter Dannenbaum , Corina Dutcus , John Infanti , Gregory Lubiniecki , Merck Co Inc , Global Clinical Development , United States Research Laboratories , Eisai Co Ltd , Vice President , United States Research , Senior Vice President , Oncology Global Clinical Development Lead ,

Merck and Eisai's Keytruda-Lenvima combo comes up short yet again, this time in endometrial cancer

Merck and Eisai's Keytruda-Lenvima combo comes up short yet again, this time in endometrial cancer
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Gregory Lubiniecki , Corina Dutcus , Merck Research Laboratories ,