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Operator Good morning, and welcome to Ionis Pharmaceuticals First Quarter 2021 Financial Results Conference Call. [Operator Instructions]. I would like to turn the conference over to Wade Walke, Vice President, Investor Relations, to lead off the call. Please begin. D. Wade Walke Vice President, Corporate Communications and Investor Relations Thank you, Betsy. Before we begin, I encourage everyone to go to the Investors section of the Ionis website to find the press release and related financial tables, including a reconciliation of the GAAP to non-GAAP financial measures that we will discuss today. We believe non-GAAP financial results better represent the economics of our business and how we manage our business. ....