Operator Good morning, and welcome to Ionis Pharmaceuticals First Quarter 2021 Financial Results Conference Call. [Operator Instructions]. I would like to turn the conference over to Wade Walke, Vice President, Investor Relations, to lead off the call. Please begin. D. Wade Walke -- Vice President, Corporate Communications and Investor Relations Thank you, Betsy. Before we begin, I encourage everyone to go to the Investors section of the Ionis website to find the press release and related financial tables, including a reconciliation of the GAAP to non-GAAP financial measures that we will discuss today. We believe non-GAAP financial results better represent the economics of our business and how we manage our business.