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Chemists and collaborators develop a new drug discovery strategy for “undruggable” drug targets
Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery opportunities.
A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells. ....

Hong Kong , Xiaoyu Li , University Of Hong Kong , Hong Kong General , Bryan Cao , Yiran Huang , Yizhou Li , Professor Of Research Division For Chemistry , Second Military Medical University , Centre For Panoromic Sciences , National Natural Science Foundation Of China , Laboratory For Synthetic Chemistry , Nature Publishing Group , Technology Commission Of Hong Kong , Research Grants Council Of Hong Kong , School Of Pharmacy , School Of Pharmaceutical Sciences , Key Laboratory Of Synthetic Chemistry , Research Division For Chemistry , Research Division , Professor Yizhou , Pharmaceutical Sciences , Chongqing University , Professor Yan , Nature Chemistry , Professor Yan Cao ,