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HKU researchers identify promising new biologics for obesity-related diseases
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Researchers identify promising new biologics for obesity-related diseases
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New chemical tool that sheds light on how proteins recognise and interact with each other
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A research group led by Professor Xiang David LI from the Research Division for Chemistry and the Department of Chemistry, The University of Hong Kong, has developed a novel chemical tool for elucidating protein interaction networks in cells. This tool not only facilitates the identification of a protein’s interacting partners in the complex cellular context, but also simultaneously allows the ‘visualisation’ of these protein-protein interactions. The findings were recently published in the prestigious scientific journal Molecular Cell.
In the human body, proteins interact with each other to cooperatively regulate essentially every biological process ranging from gene expression and signal transduction, to immune response. As a result, dysregulated protein interactions often lead to human diseases, such as cancer and Alzheimer’s disease. In modern biology, it is important to comprehensively understand protein interaction networks, which has implications in disease dia
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IMAGE: Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery. view more
Credit: The University of Hong Kong
A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.
Membrane proteins play important roles in biology, and many of them are high-value targets that are being intensively pursued in the pharmaceutical industry. The method developed by Dr Li s team provides an efficient way to discover novel ligands and inhibitors against membrane proteins, which remain largely intract