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Two proteins join forces to make flowers

What mechanisms are behind the formation of flowers? To answer this question a 25-year-old enigma has just been solved: the role of UFO protein in the.. ....

Laboratoire Physiologie Cellulaire , Structural Biology Group , Grenoble Alpes , Nature Plants , Translational Innovation , European Synchrotron Radiation Facility ,

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Structural biology at EMBL: driving technology development

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Structural biology at EMBL: driving technology development
Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field, creating ingenious inventions with worldwide impact.
First member of the MD3 diffractometer family installed at EMBL Hamburg. Credits: Kinga Lubowiecka/EMBL
Scientific breakthroughs are often only made possible by innovative technological developments. This is certainly true in structural biology, where researchers seek to gain insight into biological processes by determining the structure of macromolecules at the atomic level, for instance by X-ray crystallography or cryo-electron microscopy. Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field, creating ingenious inventions with worldwide ....

Thomas Schneider , Ralf Siebrecht , Stephen Cusack , Florent Cipriani , Tassos Perrakis , Instrumentation Team , Cipriani Team , Structural Biology Group , Team Of The Crystaldirect , Head Of The Instrumentation Team , Institut Laue Langevin , European Photon , European Synchrotron Radiation Facility , Biology Group , Crystallographic Information Management System , Science Camp , தாமஸ் ஶ்நைடர் , ஸ்டீபன் க்யூஸக் , சிப்ரியானி அணி , கட்டமைப்பு உயிரியல் குழு , ஐரோப்பிய ஃபோட்டான் , ஐரோப்பிய ஒத்திசைவு கதிர்வீச்சு வசதி , உயிரியல் குழு , அறிவியல் முகாம் ,

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works
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Rafael Fern , Titia Sixma , Meindert Lamers , Emily Henderson , Spanish National Cancer Research Centre , Loncode Institute , Leiden University Medical Center , Structural Biology Group , Netherlands Cancer Institute , Genomic Integrity , Nature Structural , ரஃபேல் ஃபெர்ன் , எமிலி ஹென்டர்சன் , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , கட்டமைப்பு உயிரியல் குழு , நெதர்லாந்து புற்றுநோய் நிறுவனம் , இயற்கை கட்டமைப்பு ,

An international study reveals how the 'guardian' of the genome works

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IMAGE: The background of the illustration is a photograph taken with the electron microscope showing DNA molecules decorated with MutS molecules, scanning the DNA for errors. The lower part shows.
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Credit: CNIO
Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication. Using cryo-electron microscopy, they made the MutS protein, also known as the guardian of our genome, visible. That enabled them to describe how this single protein is able to coordinate the essential DNA repair process from beginning to end. ....

United Kingdom , Spanish State , Rafael Fern , Titia Sixma , Meindert Lamers , United Kingdom Medical Research Council , Spanish State Agency For Innovation , Spanish Ministry Of Science , Structural Biology Group , Spanish National Cancer Research Centre , Loncode Institute , Leiden University Medical Center , Netherlands Cancer Institute , Institute Of Health , Genomic Integrity , Nature Structural , Spanish Ministry , Spanish State Agency , ஒன்றுபட்டது கிஂக்டம் , ஸ்பானிஷ் நிலை , ரஃபேல் ஃபெர்ன் , ஒன்றுபட்டது கிஂக்டம் மருத்துவ ஆராய்ச்சி சபை , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் , கட்டமைப்பு உயிரியல் குழு , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , நெதர்லாந்து புற்றுநோய் நிறுவனம் ,