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An international study reveals how the 'guardian' of the genome works


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IMAGE: The background of the illustration is a photograph taken with the electron microscope showing DNA molecules decorated with MutS molecules, scanning the DNA for errors. The lower part shows.
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Credit: CNIO
Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication. Using cryo-electron microscopy, they made the MutS protein, also known as the guardian of our genome, visible. That enabled them to describe how this single protein is able to coordinate the essential DNA repair process from beginning to end. ....

United Kingdom , Spanish State , Rafael Fern , Titia Sixma , Meindert Lamers , United Kingdom Medical Research Council , Spanish State Agency For Innovation , Spanish Ministry Of Science , Structural Biology Group , Spanish National Cancer Research Centre , Loncode Institute , Leiden University Medical Center , Netherlands Cancer Institute , Institute Of Health , Genomic Integrity , Nature Structural , Spanish Ministry , Spanish State Agency , ஒன்றுபட்டது கிஂக்டம் , ஸ்பானிஷ் நிலை , ரஃபேல் ஃபெர்ன் , ஒன்றுபட்டது கிஂக்டம் மருத்துவ ஆராய்ச்சி சபை , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் , கட்டமைப்பு உயிரியல் குழு , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , நெதர்லாந்து புற்றுநோய் நிறுவனம் ,