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Particle Size Measurement in Pharmaceutical Packaging

This article explores how you can measure particle size CQAs in (sterile) pharmaceutical packaging, and discusses non-invasive measurements using SR-DLS. ....

Carl Schuurmans , Roberta Bartucci , Fresnius Kabi , Yan Wang , Albert Grau Carbonell , Michiel Damen , Energy Industries Can , Akzo Nobel , A On The Movement Of Small Particles , Flow Pharmaceutical Research , Spatially Resolved Dynamic Light Scattering , Critical Quality Atribute , Resolved Dynamic Light Scattering , Fourier Domain Low Coherence Interferometry , Optical Coherence Tomography , Low Coherence Interferometry , Polydispersity Index , Particle Size Distribution , Formation Using , Coaxial Turbulent Jet , Small Particles Suspended , Stationary Liquids Required , Molecular Kinetic Theory , Comprehensive Review , Emulsion Stability , Energy Industries ,

Real-time process control in nanodispersion manufacturing

In this article, InProcess demonstrates the potential of in-line nanoparticle size measurements using the NanoFlowSizer (NFS) as a PAT method. ....

Eric Ardeche , Marko Verbeek , Albert Grau Carbonell , Remy Van Tuijn , Yan Wang , Carl Schuurmans , Hph Gea Xstream Lab Homogenizer , Flow Pharmaceutical Research , Pharma Inc , Energy Industries Can , Xstream Lab Homogenizer , A On The Movement Of Small Particles , Drug Administration , Rut Besseling , High Pressure Homogenization , Process Analytical Technologies , Critical Process Parameters , Critical Quality Attributes , Spatially Resolved Dynamic Light Scattering , Fourier Domain Low Coherence Interferometry , Optical Coherence Tomography , Low Coherence Interferometry , Polydispersity Index , Pressure Homogenization , Lab Homogenizer , Target Size ,

Continuous Inline Size Monitoring of Low Turbidity Suspensions

The size and size distribution of low turbidity suspensions in various (bio)pharmaceutical products, including liposomes, lipid nanoparticles, recombinant proteins, and antibodies, plays a significant role in their pharmacokinetic and pharmacodynamic profile in vivo. These factors directly influence therapeutic efficacy, immunogenicity, and safety. Consequently, particle size is considered one of the critical quality attributes for such products. ....

Carl Schuurmans , Nick Koumakis , F Hasanzadeh Davarani , Michiel Hermes , Jan Piet Wijgergangs , R Van Tuijn , Yan Wang , Louis Castel , European Journal Of Pharmaceutical Sciences , Research Unit , Pharma Inc , Bas Evers , Rut Besseling , Dynamic Light Scattering , Process Analytical Tools , Spatially Resolved Dynamic Light Scattering , Image Credit , Cumulantz Av , Inline Cumulantz Av , Offline Cumulantz Av , Bovine Serum Albumin , Antonio Costa , Adv Drug Deliv , European Journal , Low Turbidity Suspensions ,

PDF: Unique non-invasive PAT Tool for nanoparticle analysis

As inline instrument, the NanoFlowSizer is a powerful non-invasive Process Analytical Tool allowing monitoring of nanoparticle size characteristics in processes. ....

Process Analytical Tool , Spatially Resolved , Process Analytical Technologies , Spatially Resolved Dynamic Light Scattering ,

Real time online nanoparticle size monitoring

Wet bead milling is used to produce nanoparticles at industrial scales. Continuous monitoring of particle size during comminution would allow real-time end-point determination and critical quality attribute monitoring, reducing operational risk and increasing insight into particle breakage kinetics. ....

Acta Pharm , Willya Bachofen , Oral Formulation Development , Suspension Properties , Spatially Resolved Dynamic Light Scattering , Active Pharmaceutical Ingredients , Dynamic Light Scattering , Process Analytical Technologies , Resolved Dynamic Light Scattering , Online Microdilution , Sodium Docusate , Offline Zaverage Particle , Polydispersity Index , Particle Size Distributions , Wet Ultrafine Grinding , Industrial Minerals , Stirred Media Mills , Its Practical , Existing Strategies , Designing Long Acting Parenteral Formulations , Underlying Mechanisms , Size Analysis , Submicron Particles , Laser Diffractometry , Published Measurements Are , Grinding Behavior ,